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ilt 3  (Galectin Therapeutics)

 
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    Structured Review

    Galectin Therapeutics ilt 3
    Ilt 3, supplied by Galectin Therapeutics, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/ilt+3/us12590955-251-4-6?v=Galectin+Therapeutics
    Average 86 stars, based on 1 article reviews
    ilt 3 - by Bioz Stars, 2026-07
    86/100 stars

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    γ/D 3 DCs exhibit an exceptional tolerogenic phenotype. (A) Immature DCs were left untreated or treated with IFN-γ (500 U/ml), vit D 3 (10 ng/ml), or IFN-γ + vit D 3 at same concentrations. After 24 h, the DCs were washed extensively and re-stimulated using multiple CD40 ligand for an additional 24 h. Afterwards, the cell supernatants were analyzed for the presence of IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF-α. Shown are mean ± SD of four independent experiments. (B) The ratio between the capacity of D 3 DCs and γ/D 3 DCs to produce IL-10 vs. IL-12p70 was calculated by dividing mean values of both cytokines, determined in cell culture supernatants after 24 h stimulation with CD40 ligand. (C) Immature DCs were treated with various concentrations of vit D 3 (0.1 ng/ml, 1.0 ng/ml, or 10.0 ng/ml) in the presence or absence of 500 U/ml of IFN-γ. After 24 h, surface expression of ILT-3 and PDL-1 was determined using flow cytometry. Shown are mean ± SD of MFI values calculated on the basis of five independent experiments. (D) Dendritic cells were treated with vit D 3 or IFN-γ + vit D 3 for 24 h, followed by an addition 24 h exposure to LPS (20 ng/ml). Subsequently, expression of surface molecules ILT-3 and PDL-1 was analyzed and individual samples were compared to their counterpart, which was not stimulated with LPS. Shown are mean ± SD of MFIs of three independent experiments. (E) Dendritic cells were treated IFN-γ, vit D 3 , or combination of both and stained after 24 h for surface expression of different inhibitory molecules. Shown is one representative out of five independent experiments performed. The numbers on histograms represent MFI values. Statistical significance between individual pairs was calculated using Student's unpaired t -test (ns, non-significant; * p < 0.05; ** p < 0.01).

    Journal: Frontiers in Immunology

    Article Title: Synergistic Effects of Interferon-γ and Vitamin D 3 Signaling in Induction of ILT-3 high PDL-1 high Tolerogenic Dendritic Cells

    doi: 10.3389/fimmu.2019.02627

    Figure Lengend Snippet: γ/D 3 DCs exhibit an exceptional tolerogenic phenotype. (A) Immature DCs were left untreated or treated with IFN-γ (500 U/ml), vit D 3 (10 ng/ml), or IFN-γ + vit D 3 at same concentrations. After 24 h, the DCs were washed extensively and re-stimulated using multiple CD40 ligand for an additional 24 h. Afterwards, the cell supernatants were analyzed for the presence of IL-1β, IL-6, IL-8, IL-10, IL-12p70, and TNF-α. Shown are mean ± SD of four independent experiments. (B) The ratio between the capacity of D 3 DCs and γ/D 3 DCs to produce IL-10 vs. IL-12p70 was calculated by dividing mean values of both cytokines, determined in cell culture supernatants after 24 h stimulation with CD40 ligand. (C) Immature DCs were treated with various concentrations of vit D 3 (0.1 ng/ml, 1.0 ng/ml, or 10.0 ng/ml) in the presence or absence of 500 U/ml of IFN-γ. After 24 h, surface expression of ILT-3 and PDL-1 was determined using flow cytometry. Shown are mean ± SD of MFI values calculated on the basis of five independent experiments. (D) Dendritic cells were treated with vit D 3 or IFN-γ + vit D 3 for 24 h, followed by an addition 24 h exposure to LPS (20 ng/ml). Subsequently, expression of surface molecules ILT-3 and PDL-1 was analyzed and individual samples were compared to their counterpart, which was not stimulated with LPS. Shown are mean ± SD of MFIs of three independent experiments. (E) Dendritic cells were treated IFN-γ, vit D 3 , or combination of both and stained after 24 h for surface expression of different inhibitory molecules. Shown is one representative out of five independent experiments performed. The numbers on histograms represent MFI values. Statistical significance between individual pairs was calculated using Student's unpaired t -test (ns, non-significant; * p < 0.05; ** p < 0.01).

    Article Snippet: For flow cytometry analysis of DC phenotype we used the following monoclonal antibodies (mAbs): FITC-labeled anti-CD1a (clone: HI149), anti-CD1c (clone: L161), anti-CD14 (clone: 63D3), anti-CD16 (clone: 3G8), and anti-HLA I (clone: W6/32) (all from Biolegend, CA, USA); Alexa Fluor 488-labeled anti-CD4 (clone: RPA-T4) (Biolegend); PE-labeled anti-CD11b (clone: ICRF44), anti-CD11c (clone: 3.9), anti-DC-SIGN (clone: 9E9A8), anti-CD80 (clone: 2D10), anti-CD83 (clone: HB15e), anti-CD86 (clone: BU63) (all from Biolegend), and anti-HLA II (clone: AC122), anti-ILT-3 (clone: REA141), anti-ILT4 (clone: REA184), anti-PDL-1 (clone: REA1197), and anti-FasL (clone: NOK-1) (all from Miltenyi Biotec).

    Techniques: Cell Culture, Expressing, Flow Cytometry, Staining

    Tolerogenic synergy between IFN-γ and vit D 3 is independent of IDO activity and increased 25(OH)D-to-vit D 3 synthesis. (A) To exclude the enzymatic activity of IDO for the tolerogenic effects of IFN-γ and vit D 3 , we pre-treated the DCs with a highly specific IDO inhibitor Epacadostat for 2 h. Afterwards, the DCs were stimulated for 24 h and stained for surface expression of ILT-3 and PDL-1, as depicted in the figure. The results are expressed as mean ± SD of MFI from three independent experiments. (B) Dendritic cells were cultured in the presence of IFN-γ and 25(OH)D for 48 h, as depicted in the figure. Surface expression of ILT-3 and PDL-1 was evaluated after 48 h. Shown is mean ± SD of four independent experiments. Statistical analysis was made comparing individual pairs and using Student's unpaired t -test (ns, non-significant; * p < 0.05).

    Journal: Frontiers in Immunology

    Article Title: Synergistic Effects of Interferon-γ and Vitamin D 3 Signaling in Induction of ILT-3 high PDL-1 high Tolerogenic Dendritic Cells

    doi: 10.3389/fimmu.2019.02627

    Figure Lengend Snippet: Tolerogenic synergy between IFN-γ and vit D 3 is independent of IDO activity and increased 25(OH)D-to-vit D 3 synthesis. (A) To exclude the enzymatic activity of IDO for the tolerogenic effects of IFN-γ and vit D 3 , we pre-treated the DCs with a highly specific IDO inhibitor Epacadostat for 2 h. Afterwards, the DCs were stimulated for 24 h and stained for surface expression of ILT-3 and PDL-1, as depicted in the figure. The results are expressed as mean ± SD of MFI from three independent experiments. (B) Dendritic cells were cultured in the presence of IFN-γ and 25(OH)D for 48 h, as depicted in the figure. Surface expression of ILT-3 and PDL-1 was evaluated after 48 h. Shown is mean ± SD of four independent experiments. Statistical analysis was made comparing individual pairs and using Student's unpaired t -test (ns, non-significant; * p < 0.05).

    Article Snippet: For flow cytometry analysis of DC phenotype we used the following monoclonal antibodies (mAbs): FITC-labeled anti-CD1a (clone: HI149), anti-CD1c (clone: L161), anti-CD14 (clone: 63D3), anti-CD16 (clone: 3G8), and anti-HLA I (clone: W6/32) (all from Biolegend, CA, USA); Alexa Fluor 488-labeled anti-CD4 (clone: RPA-T4) (Biolegend); PE-labeled anti-CD11b (clone: ICRF44), anti-CD11c (clone: 3.9), anti-DC-SIGN (clone: 9E9A8), anti-CD80 (clone: 2D10), anti-CD83 (clone: HB15e), anti-CD86 (clone: BU63) (all from Biolegend), and anti-HLA II (clone: AC122), anti-ILT-3 (clone: REA141), anti-ILT4 (clone: REA184), anti-PDL-1 (clone: REA1197), and anti-FasL (clone: NOK-1) (all from Miltenyi Biotec).

    Techniques: Activity Assay, Staining, Expressing, Cell Culture

    The tolerogenic synergy between IFN-γ and vit D 3 is dependent on MEK/ERK and PI3K/mTOR signaling. (A) The phosphorylation status of ERK, AKT, and STAT-1 signaling proteins was determined. The DCs were stimulated with IFN-γ, vit D 3 , or IFN-γ + vit D 3 . After 1 or 24 h, the phosphorylation state of intra cellular proteins was frozen by direct addition of PFA into culture medium. The cells were then permeabilized using ice-cold methanol and stained intracellulary against pERK, pAkt, and pSTAT-1. Results are expressed as % of MFI normalized against untreated controls. Shown is mean ± SD of five independent experiments. (B) Dendritic cells were pre-treated with either inhibitor of PI3K (Ly294002), MEK/ERK (PD0325901), mTOR (rapamycin), or STAT-1 (fludarabine) for 2 h. Afterwards, the DCs were stimulated using IFN-γ and vit D 3 , for 24 h. After stimulation, the surface expression of ILT-3 and PDL-1 was analyzed. Results are expressed as mean ± SD of four independent experiments. Statistical analysis was performed using Student's unpaired t -test for determining significance between individual pairs (ns, non-significant; * p < 0.05; ** p < 0.01).

    Journal: Frontiers in Immunology

    Article Title: Synergistic Effects of Interferon-γ and Vitamin D 3 Signaling in Induction of ILT-3 high PDL-1 high Tolerogenic Dendritic Cells

    doi: 10.3389/fimmu.2019.02627

    Figure Lengend Snippet: The tolerogenic synergy between IFN-γ and vit D 3 is dependent on MEK/ERK and PI3K/mTOR signaling. (A) The phosphorylation status of ERK, AKT, and STAT-1 signaling proteins was determined. The DCs were stimulated with IFN-γ, vit D 3 , or IFN-γ + vit D 3 . After 1 or 24 h, the phosphorylation state of intra cellular proteins was frozen by direct addition of PFA into culture medium. The cells were then permeabilized using ice-cold methanol and stained intracellulary against pERK, pAkt, and pSTAT-1. Results are expressed as % of MFI normalized against untreated controls. Shown is mean ± SD of five independent experiments. (B) Dendritic cells were pre-treated with either inhibitor of PI3K (Ly294002), MEK/ERK (PD0325901), mTOR (rapamycin), or STAT-1 (fludarabine) for 2 h. Afterwards, the DCs were stimulated using IFN-γ and vit D 3 , for 24 h. After stimulation, the surface expression of ILT-3 and PDL-1 was analyzed. Results are expressed as mean ± SD of four independent experiments. Statistical analysis was performed using Student's unpaired t -test for determining significance between individual pairs (ns, non-significant; * p < 0.05; ** p < 0.01).

    Article Snippet: For flow cytometry analysis of DC phenotype we used the following monoclonal antibodies (mAbs): FITC-labeled anti-CD1a (clone: HI149), anti-CD1c (clone: L161), anti-CD14 (clone: 63D3), anti-CD16 (clone: 3G8), and anti-HLA I (clone: W6/32) (all from Biolegend, CA, USA); Alexa Fluor 488-labeled anti-CD4 (clone: RPA-T4) (Biolegend); PE-labeled anti-CD11b (clone: ICRF44), anti-CD11c (clone: 3.9), anti-DC-SIGN (clone: 9E9A8), anti-CD80 (clone: 2D10), anti-CD83 (clone: HB15e), anti-CD86 (clone: BU63) (all from Biolegend), and anti-HLA II (clone: AC122), anti-ILT-3 (clone: REA141), anti-ILT4 (clone: REA184), anti-PDL-1 (clone: REA1197), and anti-FasL (clone: NOK-1) (all from Miltenyi Biotec).

    Techniques: Staining, Expressing